COVID-19 – Day 466: Understanding the Non-Modified mRNA Vaccine from CureVac

(E) Another remarkable blog article, “the CureVac Vaccine, and a brief tour through some of the wonders of nature“, from (software engineer) blogger Bert Hubert who also wrote last year “reverse Engineering the source code of the BioNTech/Pfizer SARS-CoV-2 Vaccine“, that I used to research the work of Dr. Katalina Karikó.

While, the BioNTech and Moderna vaccines are using a chemically modified form of mRNA, the vaccine from CureVac uses unmodified mRNA!

Following is an interview with CureVac chief technology officer Mariola Fotin-Mleczek that explains it:

We spent many years researching naturally occurring mRNA molecules and now have a library of elements that can be used to build the specific mRNA nucleotide sequence needed for each specific protein. We are now leveraging this extensive expertise into the safe and rapid development and manufacturing of our Covid-19 candidate.

CureVac’s approach is to use non-modified mRNA. We believe this enables improved interactions with intracellular translation machinery, leading to high protein production and a moderate activation of innate immunity. We also believe this approach closely mimics the natural immune response to Covid-19; our studies confirm that we see similar ratios of binding and neutralizing antibodies in vaccinated individuals and convalescent patients.

The dose of CVnCoV proposed for Phase IIb/III trial is the lowest dose of any of the mRNA vaccine candidates in advanced clinical trials. Our optimization process enables high expression levels of the encoded protein, which ultimately means we can use a lower dose.”

Note: The picture above is from the historical estate and gardens Filoli, and its current exhibition of tulips.

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Categories: Coronavirus